Adam and Steve are two gay youths who have a one-night stand that ends embarrassingly. Nearly two decades later, Adam, now a Manhattan tour guide, and Steve, a psychiatrist, meet again -- but neither remembers the other from years before. The two begin dating, even playing matchmaker for their friends Michael and Rhonda, but their promising relationship hits a major snag when Adam and Steve finally recall their past connection.
A scientist and his sidekick accidentally clone a journalist and decide to turn the mistake into Repli-Kate, their idea of the perfect woman, who loves, beer, football, and frat parties.
Psychopath Debbie Strand escapes from a mental institution for the criminally insane and takes the identity of a co-ed she meets and sets herself up on a college campus where she once again begins killing students who get in the way of her obsession with her former high school teacher Sam Deckner now teaching at the college.
Following a bomb scare in the 1960s that locked the Webers into their bomb shelter for 35 years, Adam now ventures forth into Los Angeles to obtain food and supplies for his family, and a non-mutant wife for himself.