French nuclear tests irradiate an iguana into a giant monster that viciously attacks freighter ships in the Pacific Ocean. A team of experts, including Niko Tatopoulos, conclude that the oversized reptile is the culprit. Before long, the giant lizard is loose in Manhattan as the US military races to destroy the monster before it reproduces and it's spawn takes over the world.
U.S. Marshal Sam Gerard is accompanying a plane load of convicts from Chicago to New York. The plane crashes spectacularly, and Mark Sheridan escapes. But when Diplomatic Security Agent John Royce is assigned to help Gerard recapture Sheridan, it becomes clear that Sheridan is more than just another murderer.
After a stripper tricks him into filming a sex tape, Miami rickshaw runner Scott Edwards becomes embroiled in the murder of a televangelist's son when he inadvertently takes the wrong videotape. With the help of the stripper and a witch, Edwards sets out to clear his name while avoiding the assassin dead-set on retrieving the tape.
New York's Odyssey Detective Agency is hired by two different clients to follow two women suspected of infidelity. Ladies' man John Russo trails Angela Niotes, the elegant wife of a wealthy Italian industrialist, while Charles Rutledge and Arthur Brodsky follow Dolores Martin, the beautiful young wife of a jealous husband. Their respective cases are complicated when John falls for Angela, and Charles falls for Dolores.
New York comedian Alvy Singer falls in love with the ditsy Annie Hall.