After regaining his manliness, he escapes from hell Satan for embezzling Secretary of infernal hacienda, being chased by a couple of poor devils good for nothing, and took refuge in the cabaret ends up working as a transvestite.
When Santo accompanies a troupe of archaeologists in the search for Aztec artifacts, they find the Mummy of an Aztec who leaves a warning to those who tamper with his resting place. The adventurers ignore the warning, and before long, the Mummy starts bumping them off one-by-one with his bow & arrow.
After a group of violent lepers escapes from a sanitarium, - robbing several farms, residents of the town demand the the sheriff - take action. Meanwhile, a local criminal joins forces with the lepers - to commit even more robberies. As the disfigured madmen keep the - entire town indoors with its reign of terror, the sheriff has no - choice but to call on the only man who can help--legendary wrestling - superhero, Santo!
Santo must battle an evil witch and the demons and evil spirits she brings up from Hell.
Young priest Father Sebastián is assigned to a parish in San Jeronimo el Alto, where he is not welcomed by the community, particularly the resident priest Father Damián. The newcomer gradually earns the trust of the people through humor, but firmly captures their hearts by saving the town fiesta by fighting a bull when the hired torero failed to show. Father Sebastián counsels the townspeople, lecturing them on their duties in a modern society. He used the collection plate to redistribute the town's wealth more evenly.