Unlucky assassin Ladybug is determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe—all with connected, yet conflicting, objectives—on the world's fastest train.
Phil and Claire Foster fear that their mild-mannered relationship may be falling into a stale rut. During their weekly date night, their dinner reservation leads to their being mistaken for a couple of thieves—and now a number of unsavoury characters want Phil and Claire killed.
In Dallas, witnesses against a drug-lord are murdered in a safe-house.The testimony of FBI agents becomes the only chance to keep him in prison. They are lodged in another safe-house, but the place is invaded and the agents are executed. However, Kate is only wounded, and her boyfriend Nick believes there is a traitor in the agency and takes her to his ranch to protect her life.
Abducted couples are victims of medical experiments that mutate their minds with supernatural abilities. As their mental capacities increase, so does the danger from something evil that is not of flesh and blood.