In the not too distant future, a captive woman undergoes psychological and emotional testing by her abductor. As she tries to escape, she learns that he may not be her biggest concern.
After a comet releases a mysterious virus that begins to kill all of the women in the world, a young couple's relationship is severely tested. They hide out (from both the illness and the savages who hunt the remaining women) in their over-sterilized apartment. Ultimately the duo escapes their self-imposed quarantine to head to the wilderness.
Carmilla inadvertently infects Ron, Fang, and Corey with her vampirism. Unaware of their condition, these three misfit vampires' hysterical misadventures illuminate the sudden changes in their nature. While attending a support group recommended by Dr. Acula for what is thought to be a medical condition, the three connect back with Carmilla and learn the truth of their new existence. Cast out by Martin and the old vampires, pursued by the determined Eddie Van Helsing, Ron and Carmilla seek to maintain some humanity and lead their menage through the challenges of vampire life in the modern world.
Ferrari Thunderbird Taylor is a foul-mouthed, perpetually buzzed vigilante who, after getting out of rehab, has her heart set on proposing to her boyfriend, Harry Shumway. But when she realizes that the object of her affection is running for South Carolina governor on a platform of seceding from the United States, she races to save her man, if not the entire state, from certain ruin.