It is the story of Eleanor, a good housewife who lives with her husband, Fernando, and their two children. Deeply loves her husband and does not question the reciprocity of love and fidelity. One day, circumstantially, discovers her husband is cheating. Leonor emotionally feels betrayed and realizes that his world, based on a lie, has collapsed like a house of cards. With more fear than conviction, leaving the house, leaving little signs with instructions for their march and trust their children to the care of her husband.
While on tour through Latin America, los Grandes del Buen Humor are confused with volunteers for a space travel and get tangled with spies.
Four men, known for their reckless actions, are arrested one night after ruining a dinner party. They are soon released and go to visit their uncle who is sick. The four of them decide to travel to Africa to try to find a cure for their uncle, but they get into a big mess.