Two inmates and a cleaning girl at a home for struggling artists achieve success and fame when they pool their talents and produce a smash hit Broadway musical. Edgar ( Monte Blue ), the playwright, is in love with April ( Madge Kennedy ), the ex- leading lady, but she doesn't discover that she loves him until it's almost too late.
Lillian Travers, a New York heiress, pops down to Florida to surprise her fiancé, Fred Cassadene, the house doctor at a prominent Saint Augustine hotel. The surprise, however, is Lillian's when she finds Fred in a series of compromising situations with a certain wealthy widow staying there. When she can take no more, Lillian discovers a box forgotten at an old curiosity shop in which lies a hundred-year-old secret: a vial of four rare and exotic African seeds that promises to transform whoever swallows one from a woman to a man or vice versa.
Agnes Belgradin is in love with a young doctor, Loring Brent. When Agnes' father dies, her mother takes her on a trip abroad. She insists that the young couple separate before they set sail, and promises that if they still love each other after a year they can reunite. But Mrs. Belgradin intercepts all the letters Agnes and Brent write one another, and convinces her daughter to marry a wealthy Australian millionaire.
Miser Ebenezer Scrooge is awakened on Christmas Eve by spirits who reveal to him his own miserable existence, what opportunities he wasted in his youth, his current cruelties, and the dire fate that awaits him if he does not change his ways. Scrooge is faced with his own story of growing bitterness and meanness, and must decide what his own future will hold: death or redemption.
When Viola and her twin brother Sebastian are shipwrecked and separated, Viola dresses in her brother's clothes and becomes a page in the palace of the Duke of Orsino. Thinking Viola is a boy, the Duke sends her with a message to Olivia, whom he loves. A series of complications begins when Olivia falls in love with the page 'boy'
Released in five parts (The Persecution of the Children of Israel by the Egyptians, Forty Years in the Land of Midian, The Plagues of Egypt and the Deliverance of the Hebrews, The Victory of Israel, The Promised Land), 4 December 1909 to 19 February 1910. A Vitagraph advertisement in the Moving Picture World (31 Dec. 1909) refers to The Life of Moses as a "Biblical Film-de-Luxe". It is preserved in the Library of Congress collection.