Now in the Far North (i.e. Milan!), Alberto has accepted to manage a program for efficiency improvement in the Italian Post. He devotes all his time and all his energy to this noble task and neglects his wife Silvia, which of course annoys her beyond limits. Things do not fare much better in Castellabate where it is rather Maria, Matta's wife, who gets on his nerves by always blaming him for his lack of ambition. One day, due to a misunderstanding, Mattia is transferred to... Milan! And on whose doorstep does he land? Alberto's of course!
The film follows Nello, the recently hired director of a newly developed work cooperative of former mental patients. After the closure of state psychiatric hospitals and asylums in Italy under the Basaglia Law many former patients were left with few resources and little hope of reintegrating into society. With the intention of actually improving the lives of his pupils, rather than just sedating them, Nello encourages them to expand their individual abilities and explore the wider world around them although, regardless of intention, there is sometimes a price to pushing boundaries too quickly.
Policewoman Anna Mari is forced to play a dangerous game with the title serial killer. If she loses, she witnesses the maniac's tortured victims having their throats cut in explicit close-up detail via webcam. She teams up with British cop John Brennan to find out the identity of the murderer.