Janice is the subject of the town gossips for four reasons: she wears too much lipstick, her hair is too big, she is a single-mother and her two children are strange. Ray (6) is a hellraiser and Tony (9) is autistic. One day, however, Tony sits down at the piano and plays Twinkle Twinkle Little Star, and Janice knows there may be hope for him (and them) yet.
Margaret, who has certain mental disabilities, struggles when her husband, Jake, is diagnosed with schizophrenia and the authorities wish to take her children away from her. She has to prove in a court of law that she is capable of taking care of her family.
Ever since Pam Cheney (Cheryl Ladd) lost her baby during labor, she has been struggling with depression. She is not only supported by her loving, but hard working husband Sean (Robert Desiderio), but also by her friends Ella (Polly Draper) and Terry Sabin (D. David Morin), who have also lost a baby at age three. One year after labor, Pam decides to finally take a proposal to adopt a toddler. Going through official agencies proves unsuccessful, partly due to Pam's age, partly due to the growing demand of adoption. She is advised to take care of an orphaned teenager instead, but Sean refuses this option.
Steve Thompson is losing himself, one memory at a time. Plagued with amnesia after getting a concussion, Steve is overwhelmed by his unrecognizable life and leaves his family in search of answers. But his quest only returns him back home, where he must face his demons and get at the truth.
While waiting for her divorce papers, a repressed literature professor finds herself unexpectedly attracted by a carefree, spirited young woman named Cay.