Chuck and Buck are childhood best friends whose lives have taken very different paths. While Chuck moved away and now has a real life, Buck stayed behind and developed a dangerous fixation—on Chuck's life.
One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.
Carlos wants to be an actor. But his father, Pepe, wants him to work in the family business, that is, male prostitution. Carlos decides that he will be one of his father's boys until he can get his foot in the door in Hollywood.