Delos is a futuristic amusement park that features themed worlds—ancient Rome, Medieval times and the Old West—populated by human-like androids. After two patrons have a run-in with a menacing gunslinger in West World, the androids at Delos all begin to malfunction, causing havoc throughout the park.
In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.