Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.
Two overworked and underpaid assistants come up with a plan to get their bosses off their backs by setting them up with each other.
In a surreal motel in Los Angeles, the life of several sordid characters intertwine.
An innocent couple suddenly finds themselves thrust into an unbelievable adventure involving underwater treasures, maniacal gangsters, violent gunplay and non-stop chances in trains cars and boats, when they witness a luxury boat explosion in the small town of Oyster Creek and receive a cryptic message from a dying victim they attempt to rescue.