Following a bomb scare in the 1960s that locked the Webers into their bomb shelter for 35 years, Adam now ventures forth into Los Angeles to obtain food and supplies for his family, and a non-mutant wife for himself.
Down-on-their luck brothers, Lars and Ernie Smuntz, aren't happy with the crumbling old mansion they inherit... until they discover the estate is worth millions. Before they can cash in, they have to rid the house of its single, stubborn occupant—a tiny and tenacious mouse.
Shakes plods about his duties as party clown, and uses all of his free time getting seriously drunk. Binky, another clown, wins the spot on a local kiddie show, which depresses Shakes even more, and his boss threatens him with unemployment if he can't get his act under control.
As they enter their third year of medical school, a group of young students must prepare to decide what they intend to specialize in. Somehow, they must impress the Chief of Surgery while learning how to survive the life-and-death area of medicine and the complexity of their everyday lives.