In New York City, Thom is broke and jobless, illegally working as a taxi driver. Claire is a successful business-woman, but personally she's in shambles - then comes the phone call that her estranged father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive and so he does. They find themselves in Pennsylvania and Claire makes the rash decision to drive across the country to California. On the road, there are many detours as the obstacles and secrets force them to learn about themselves and each other.
Intertwined tales of three families who grow up on the same street, focusing on the relationship of fathers and sons. The first section features Anthony and Jenny and traces the father-son bond that develops between Anthony and his newborn son over 30 years. The second story centers on the affairs of an airline pilot who shares a house but not a life with his wife. He crosses paths with an unusual woman and spends an extraordinary night with his son. The final chapter follows the homecoming of Elliot to his estranged family. As his father dies, Elliot meets and falls in love with a woman who sees past his tough-guy exterior.
The miniseries featured James Brolin as Ronald Reagan and Judy Davis as Nancy Reagan, and covers the period in time from 1949 when Reagan was still in Hollywood, through his governorship of California until Reagan's last day in office as President in 1989.