A government program poisons millions. An immune grandfather-granddaughter duo survive, hunted by ruthless scalpers and an official determined to save his son, leading to a fight for survival amidst the chaos.
The police try to arrest expert hostage negotiator Danny Roman, who insists he's being framed for his partner's murder in what he believes is an elaborate conspiracy. Thinking there's evidence in the Internal Affairs offices that might clear him, he takes everyone in the office hostage and demands that another well-known negotiator be brought in to handle the situation and secretly investigate the conspiracy.