Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
A band of murderous cowboys has imposed a reign of terror on the town of Warlock. With the sheriff humiliatingly run out of town, the residents hire the services of Clay Blaisedell as de facto town marshal. He arrives along with his friend, Tom Morgan, and sets about restoring law and order on his own terms whilst also overseeing the establishment of a gambling house and saloon.
Two brothers discharged from the Confederate Army join a businessman for a cattle drive from Texas to Montana where they run into raiding Jayhawkers, angry Sioux, rough terrain and bad weather.
Cattle baron Matt Devereaux raids a copper smelter that is polluting his water, then divides his property among his sons. Son Joe takes responsibility for the raid and gets three years in prison. Matt dies from a stroke partly caused by his rebellious sons and when Joe gets out he plans revenge.
Late in the Civil War, three Confederate soldiers escape from a Union prison camp in Missouri. They soon fall into the hands of pro-Confederate raiders, who force them to act as "outriders" (escorts) for a civilian wagon train that will be secretly transporting Union gold from Santa Fe, New Mexico, to St. Louis, Missouri. The three men are to lead the wagons into a raider trap in Missouri, but one of them starts to have misgivings....
A surveyor for the Canadian Pacific Railroad must fight fur trappers who oppose the building of the railroad by stirring up Indian rebellion.
A boy haunted by nightmares about the night his entire family was murdered is brought up by a neighboring family in the 1880s. He falls for his lovely adoptive sister but his nasty adoptive brother and mysterious uncle want him dead.
A city girl on a bus tour of the West encounters a handsome rodeo cowboy who helps her forget her city suitors.
Boston pharmacist Tom Craig comes to Sacramento, where he runs afoul of local political boss Britt Dawson, who exacts protection payment from the citizenry. Dawson frames Craig with poisoned medicine, but Craig redeems himself during a Gold Rush epidemic.
The story follows General George Armstrong Custer's adventures from his West Point days to his death. He defies orders during the Civil War, trains the 7th Cavalry, appeases Chief Crazy Horse and later engages in bloody battle with the Sioux nation.