Pedro, Arturo and Eligio are three college professors who lost their job because of economic crisis. Accidentally they find a solution for all of their problems; a multi-vitamin that allows them to party all night long without any side effects. The three professors will be launched into the world of nightclubs and the shady business, in order to market the merchandise. Of course, it seems that they are not as prepared for it as they thought.
Today is the most important day in the lives of Suso and Ricard: after several years in a relationship they're going to get married. Ricard comes from a Catalan family of rancid lineage; Suso, from a humble one in La Mancha. Both of their families are delighted with the marriage. Well, not all: Adela, Suso's grandmother, will be present at the dinner, but unaware that what's being celebrated is her grandson's wedding day.
Javi, Hugo, Dani and Pedro are four friends in their late twenties trying to make a life for themselves. The cafe is where the buddies meet through the ups and downs of fast-paced lives full of basketball games, late-night partying and schemes to get what they want most: a little love and a girl who loves them.
Tony is a young crook preparing for a bank robbery with her boyfriend Juanjo and their low-life partners Maxi and Moco. Right before they commit the crime, Juanjo informs Tony that his prostitute sister wants him to take her young daughter Laura to visit the girl's father, a flamenco singer in the Spanish southern coastal town of Tarifa. Juanjo persuades the initially reluctant Tony that Laura will provide the couple with a perfect cover after they relieve their partners of the robbery's earnings. Unfortunately, though the robbery comes off without a hitch, the duplicitous Juanjo absconds with the cash, making Tony and Laura fugitives both from the law and from the psychotically angry Maxi and Moco.