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Favino was born in Rome, Italy.
He has appeared in more than forty European films and television series' since the early 1990s, including Gabriele Muccino's The Last Kiss, Gianni Amelio's The Keys to the House, Giuseppe Tornatore's The Unknown Woman and Ferzan Özpetek's Saturn in Opposition.
In 1999 he starred in the HBO film Excellent Cadavers, adaptation of Alexander Stille's novel of the same name.
He received the David di Donatelloaward - Italian equivalent of the Oscar - in 2006 for his role in the crime film Romanzo Criminale, directed by Michele Placido.
In the immediate post-war period, amidst the rubble of a poverty-ridden Naples, two kids, Carmine and Celestina, try to survive as best they can by helping each other out. One night, they secretly board a ship bound for New York to reach Celestina’s sister, who emigrated to America several years earlier. The two children join the many Italian emigrants seeking a new life in America and arrive in an unknown metropolis, which, after several misadventures, they will learn to call home.
Edmond Dantes becomes the target of a sinister plot and is arrested on his wedding day for a crime he did not commit. After 14 years in the island prison of Château d’If, he manages a daring escape. Now rich beyond his dreams, he assumes the identity of the Count of Monte-Cristo and exacts his revenge on the three men who betrayed him.
On the night before his retirement, police lieutenant Franco Amore is called to investigate the death of a long-time partner of his in a diamond heist in which he was involved.
Everyone in Marco's life seems constantly restless, from his brilliant but unhappily married parents to his own wife Marina, or even Luisa, the real love of his life, a girl he met during a fateful summer in the '70s and always stayed in touch with. Tragedy and fate seem to haunt him, yet he somehow manages never to get ensnared in the chaos—like his namesake, “the hummingbird”, he focuses all his energy at standing still.
Palermo, Sicily, 1980. Mafia member Tommaso Buscetta decides to move to Brazil with his family fleeing the constant war between the different clans of the criminal organization. But when, after living several misfortunes, he is forced to return to Italy, he makes a bold decision that will change his life and the destiny of Cosa Nostra forever.
Former major league baseball player Moe Berg lives a double life working for the Office of Strategic Services in World War II Europe.
A young Englishman plots revenge against his mysterious, beautiful cousin, believing that she murdered his guardian. But his feelings become complicated as he finds himself falling under the beguiling spell of her charms.
A G8 meeting is being held at a luxury hotel on the German coast. The world's most powerful economists are gathered to enact important provisions that will deeply influence the world economy. One of the guests is a mysterious Italian monk, invited by Daniel Rochè, the director of the International Monetary Fund. He wants the monk to receive his confession, that night, in secret. The next morning, Rochè is found dead...
A gangster known as "Samurai" wants to turn the waterfront of Rome into a new Las Vegas. All the local mob bosses have agreed to work for this common goal. But peace is not to last long.
Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.
Anna is an accountant for an important insurance firm and lives with her longterm lover Alessio - a man who longs for a stable longterm relationship with children, home, etc. Anna, feeling as though the fire has fizzled in that relationship takes up with co-worker Domenico and the two begin a passionate affair.
Harvard symbologist Robert Langdon is recruited by the Vatican to investigate the apparent return of the Illuminati – a secret, underground organization – after four cardinals are kidnapped on the night of the papal conclave.
One year after their incredible adventures in the Lion, the Witch and the Wardrobe, Peter, Edmund, Lucy and Susan Pevensie return to Narnia to aid a young prince whose life has been threatened by the evil King Miraz. Now, with the help of a colorful cast of new characters, including Trufflehunter the badger and Nikabrik the dwarf, the Pevensie clan embarks on an incredible quest to ensure that Narnia is returned to its rightful heir.
Irena, a Ukrainian woman, comes to Italy looking for a job as a maid. She does everything she can to become a beloved nanny for an adorable little girl, Thea. However, that is just the very beginning of her unknown journey.
War seen through the eyes of Serra, a university student from Palermo who volunteers in 1942 to fight in Africa. He is assigned to the Pavia Division on the southern line in Egypt. Rommel and the Axis forces are bogged down; it's October, the British prepare an offensive. At first, boredom, heat, hunger, and thirst bedevil the Italians; then the Brits attack, and there's no luck or heroism in death. Finally, it's retreat in confusion. Serra, his sergeant Rizzo, and his lieutenant Fiori take a last walk toward home. It's said that each soldier gets three miracles; when Serra's are used up, what then?