When video creator Angie knocks on the door of the City Hunter detective agency looking for a missing cat, Ryo Saeba and Kaori Makimura think they have a simple case on their hands. But an attempt on Angie's life changes the game, leaving Ryo in the crosshairs of mysterious assassins on the trail of Angel Dust, a military technology capable of creating super soldiers. Under the watchful eye of his adoptive father Kaibara, Ryo will have to deal with a past he has tried to escape for too long.
News about the disappearance of panties is still being covered every day. Kyosuke still wears Aiko Completo's panties to battle evil. Meanwhile, Aiko has mixed emotions and decides to get her panties back. Kyosuke suffers from the loss of Aiko's panties and disappears, but his biggest enemy yet is about to materialise.
During Muraishi's time in prison for fraud, he recalls his past and learns a power to penetrate and cure others. Upon release, he goes to Hakodate, where he can find his ex-wife, Kiriko. Though he cures a lot of people on the way and believes that he is the only one to make Kiriko happy, he is being depressed by discovering a guy together with her.
Hiromi appears on the outside to be a mature, resilient girl, but on the inside she feels like she's falling apart. She is having troubles at home mainly because of her parents wanting to separate. Her dog, Junkers, tries to comfort her in ways no other dog can. You see, he can talk and grant her 3 wishes.
Living in London with her family, Carol is the daughter of a famous musician, Lionel Mudagolas. While he is currently having difficulties playing his cello, she occasionally starts to listen an unfamiliar voice calling her name. Wondering if her father's situation might be connected to the bad phase of her favorite band, Gable Screen, and the inexplicable silence of the Big Ben, Carol is suddenly transported to another world. There she finds out that she might be the girl predestined to fight Gigantica, a demon lord who recently brought chaos to this strange land.