Maggie is an uptight, single mother and college writing teacher from New York City. In an effort to reconnect with her troubled teen daughter Summer, she decides to embark on a journey to a Tuscan village where she frequented in her younger days. Upon arrival, Maggie runs into Luca a handsome former lover who is still a bachelor and lives with his eighty-year-old mother Carmen. Summer (missing her “bad boy” boyfriend in NYC) and Carmen (secretly planning a wedding against Luca’s wishes to MARCELINO, her one true love in Rome) impulsively steal Luca’s car and race off to Rome. Maggie and Luca quickly pursue allowing the two mismatched couples to spend some time together and develop a new understanding of each other.
Living among boys is easy, each of them with their own mess, unregimented lifestyle, and unique "method of study." The male universe in which they live, however, is about to be invaded by women. Giorgia is independent and receives little attention from her parents; Francesca is in a doomed relationship with an older professor, while Emma wants to be a famous performer. In this new mixed arrangement house, each character finds their place as they establish a confusing, but fun and tumultuous extended family - a family which none of them has ever truly had.
Ulisse, Fulvio and Domenico decide to rent an apartment together in order to live with their modest work. However the three encounter any difficulties that have forced them to always be one step away from starvation. Ulisse has to maintain his wife and daughter selling recordings of important foreign singers, Fulvio has the task of reviewing silly scandals of celebrities instead of writing articles for major artists, while Domenico must keep his wife and children going to make love with old single pensioners.
Valerio is a famous advertising man who is going through a deep crisis of inspiration. His company is also going through a difficult time but the man gets the fundamental help of his sister Barbara and his brother-in-law Giulio, who offer him a considerable sum of money if he will take care of their son's dog, since they will be abroad for some time. Too bad Valerio can't stand dogs, but when he's forced to accept and starts taking care of Spugna: it will be the beginning of an experience that will change him in an unexpected way.