Barry Munday, a libido-driven wage slave who spends all his time either ogling, fantasizing about or trying to pick up women, wakes up in hospital after a freak attack only to find that his testicles have been removed.
In Venice Beach, naive Midwesterner JB bonds with local slacker KG and they form the rock band Tenacious D. Setting out to become the world's greatest band is no easy feat, so they set out to steal what could be the answer to their prayers... a magical guitar pick housed in a rock-and-roll museum some 300 miles away.
Kay and Jay reunite to provide our best, last and only line of defense against a sinister seductress who levels the toughest challenge yet to the MIB's untarnished mission statement – protecting Earth from the scum of the universe. It's been four years since the alien-seeking agents averted an intergalactic disaster of epic proportions. Now it's a race against the clock as Jay must convince Kay – who not only has absolutely no memory of his time spent with the MIB, but is also the only living person left with the expertise to save the galaxy – to reunite with the MIB before the earth submits to ultimate destruction.
Physicist Eva Soderstrom discovers greedy industrialist Thomas Abernathy is on the verge of creating an artificial black hole in a laboratory on Earth. It's the same experiment that killed her father years earlier, except bigger. With the help of Dr. Price, Eva tries to stop Abernathy and, possibly, save the planet
Lily is a twenty-something aspiring writer who receives an invitation to attend a wedding reception with Jonathan, a handsome entomologist who also happens to be the man of her dreams. The only problem is that she's in San Francisco and the wedding is in L.A. Lily is therefore forced to enlist the aid of her friend Frances, an unrepentant party girl who has the L.A. nightclub scene wired. Their plans are completely derailed when they inadvertently lose the all important wedding invitation. This sets in motion an evening full of near misses with Jonathan, and thrusts Lily and Frances into a swarm of offbeat encounters with the underground Hollywood crowd. Off they go from club to club, from party to party and from boy to boy in an effort to find the wedding reception.
When recently single Steven moves into his new apartment, cable guy Chip comes to hook him up—and doesn't let go. Initially, Chip is just overzealous in his desire to be Steven's pal, but when Steven tries to end the 'friendship', Chip shows his dark side. He begins stalking Steven, who's left to fend for himself because no one else can believe Chip's capable of such behaviour.
A crazed killer sneaks onto the set of a sci-fi film and begins murdering the cast and crew.