Will Handy grows up in Memphis with his preacher father and his Aunt Hagar. His father intends for him to use his musical gifts only in church, but he can't stay away from the music of the streets and workers. After he writes a theme song for a local politician, Gogo, a speakeasy singer, convinces Will to be her accompanist. Will is estranged from his father for many years while he writes and publishes many blues songs. At last the family is reunited when Gogo brings them to New York to see Will's music played by a symphony orchestra.
Hardworking Minnie (Cora Green) marries "Dollar" Bill (Bud Harris) a shady gambler after her money and her attractive daughter, Sue (Izanetta Wilcois). Sue meanwhile, is in love with Bob (Carl Hough), an idealist fond of looking out over the skyline and saying "Harlem... there's so much to be done here--it's fairly screaming for leadership." When Bob decides to organize the community against local racketeers he little realizes would-be father-in-law Dollar Bill is one of them. Bill meanwhile has problems of his own: A vicious white mob from lower Manhattan is muscling in on his action, and bullets are about to fly.