The story follows General George Armstrong Custer's adventures from his West Point days to his death. He defies orders during the Civil War, trains the 7th Cavalry, appeases Chief Crazy Horse and later engages in bloody battle with the Sioux nation.
A publicity man promotes his newspaper, but finds his boss always steals the credit.
Newspaper reporter Michael Ward plunges into a nightmare of guilt, fearing that his "evidence" has sentenced the wrong man to death.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
Nightclub owner Steve Larwitt sees his empire of investments collapse as he faces tax evasion charges and attacks by rivals. Believing Steve will be safer in prison for one year, his wife, Brenda, testifies against him on advice from his lawyer, Slant Kolma, who is in love with her. After Steve receives 10 years in Alcatraz, Brenda moves to be near him and avoids advances of airplane builder Tim Nolan, who knows nothing about her past.
Embittered after serving time for a burglary he did not commit, Joe Bell is soon back in jail, on a prison farm. His love for the foreman's daughter leads to a fight between them, leading to the older man's death due to a weak heart. Joe and Mabel go on the run as he thinks no-one would believe a nobody like him.
A young man just released from a reformatory moves to a new neighborhood with his sister, intending to start a new life. However, he gets mixed up with the local mob boss and corrupt politicians and soon finds himself being framed for an arson and murder he didn't commit.
A corrupt D.A. with governatorial ambitions is annoyed by an investigative reporter's criticism of his criminal activities and decides to frame the reporter for manslaughter in order to silence him.
Physician Carole Nelson, suspected of having ties to notorious gangster Joe Gurney, must prove her innocence or the Medical Board will revoke her license. When Gurney seeks her out for treatment after being shot, it could be the break Nelson needs. Now she has a chance to use her medical know-how to outwit Gurney and his goons and reestablish her professional reputation.
Jim 'Socker' Conway, former boxer and FBI hero, is maneuvered for political reasons into a do-nothing job in the district attorney's office. Meanwhile, he meets wild debutante Letty Lane, girlfriend of mob mouthpiece Steve Lawrence; and Letty's much nicer sister Susan. Now the slot machine gang brutally beats Jim's friends Franz and Otto. And Jim finds a way to use his nominal position to go into the racket- busting business. But his success puts Letty in deadly peril...
Madcap couple George and Marion Kerby are killed in an automobile accident. They return as ghosts to try and liven up the regimented lifestyle of their friend and bank president, Cosmo Topper. When Topper starts to live it up, it strains relations with his stuffy wife.
Fight promoter Nick Donati grooms a bellhop as a future champ, but has second thoughts when the 'kid' falls for his sister.
A Navy veteran with one leg fights to make himself a success.
In the underworld of Manhattan, a woman dares to stand up to one of the city's most powerful gangsters.