An ancient urn is found in a cemetery outside Rome. Once opened, it triggers a series of violent incidents: robberies, rapes and murders increase dramatically, while several mysterious, evil-looking young women coming from all over the world are gathering in the city. All these events are caused by the return of Mater Lacrimarum, the last of three powerful witches who have been spreading terror and death for centuries. Alone against an army of psychos and demons, Sarah Mandy, an art student who seems to have supernatural abilities of her own, is the only person left to prevent the Mother of Tears from destroying Rome.
A detective with PTSD investigates the disappearance of several junk TV celebrities who have all been guests at the same controversial talk show.
Plagued by financial problems, ne'er-do-well Guido ends up in jail after faking an armed robbery at his workplace. A year later, just a few days before his release, he's forced by two dangerous inmates to take part in their jailbreak. On the run, Guido sets out to find his partner Antonella, who helped him with the robbery and still has the money.