Harry "Rabbit" Angstrom comes home one day from his dead-end job to find his pregnant wife Janice asleep, splayed in front of the TV, highball glass in hand. After a moment's contemplation, he decides to leave. Taking his coat and car keys, he's off and running on a rambling, aimless journey.
In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.
Federal Airlines ace pilot Chick Faber is grounded by Flight Superintendent Bill Graves when a doctor says his eyesight is failing. Aided by Mary Norvell and Nan Hudson, Graves persuades Chick to take a job as teacher in the school for airline hostesses, and Chick and Mary get married. He learns that the Army is going to test a stratosphere plane that he and Artie Dixon designed and feels that he should make the first flight but permission is refused.
An inventor and his bride get testy in the city as they try to make ends meet.
Philo is in Vienna working for the US Government to see if Archer Coe is selling aircraft designs to foreign powers. He grabs the plans with Archer's signature, but is captured by police before he can escape. Deported he comes back to America and plans to confront Archer, but Archer is found dead in his locked bedroom with a gun in his hand. While it looks like a suicide, Vance knows better and the coroner finds that Archer has been shot, hit with a blunt instrument and stabbed - making suicide unlikely. But Vance is on the case and is looking to see if government secrets have been sold and who has murdered Coe. This is a remake of "The Kennel Murder Case" using aircraft designs and espionage instead of Chinese porcelain and dog shows.