In this strange western version of Moby Dick, Wild Bill Hickok hunts a white buffalo he has seen in a dream. Hickok moves through a variety of uniquely authentic western locations - dim, filthy, makeshift taverns; freezing, slaughterhouse-like frontier towns and beautifully desolate high country - before improbably teaming up with a young Crazy Horse to pursue the creature.
Pursued by 2,000 US soldiers and cavalry, Chief Joseph leads his tribe of 800 Nez Perce on a 1,700 mile journey across the West and towards Canada. Based on the true story of the westward expansion of the United States and the military force used to displace Native Americans from their lands.
Due to an experimental vaccine, Dr. Robert Neville is the only human survivor of an apocalyptic war waged with biological weapons. Besides him, only a few hundred deformed, nocturnal people remain - sensitive to light, and homicidally psychotic.