A man wakes up alone in the middle of the desert with a black hood on his head and his hands tied behind his back. At death's door, he is discovered by a woman living alone in the desert and is nursed back to health. Upon regaining consciousness, the man realizes he has amnesia, and has no idea who he is. His only clue, a piece of paper in his pocket with the name "Manny Elder" on it, sends him on a journey to Los Angeles to discover his past. But things and people are not what they seem and clues lead to something bigger and more unusual than the man could have ever imagined.
In New York City, Thom is broke and jobless, illegally working as a taxi driver. Claire is a successful business-woman, but personally she's in shambles - then comes the phone call that her estranged father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive and so he does. They find themselves in Pennsylvania and Claire makes the rash decision to drive across the country to California. On the road, there are many detours as the obstacles and secrets force them to learn about themselves and each other.
Widowed U.S. president Andrew Shepherd, one of the world's most powerful men, can have anything he wants -- and what he covets most is Sydney Ellen Wade, a Washington lobbyist. But Shepherd's attempts at courting her spark wild rumors and decimate his approval ratings.
A deadly airborne virus finds its way into the USA and starts killing off people at an epidemic rate. Col. Sam Daniels' job is to stop the virus spreading from a small town, which must be quarantined, and to prevent an over reaction by the White House.