A doctor kidnaps couples who are having sex and takes them to his mansion where they are being kept as prisoners. He injects his subjects with a substance to 'enhance' their sexual abilities. The curious doctor then forces the abducted people to have sex. While they are making love he drains a fluid from them. He needs this to prevent himself from being transformed into a monster. He gets his instructions from a talking brain.
Ofelia's wedding day is approaching and she is to be married to Eduaurdo. She has some pre-wedding jitters during a meeting with her lover Gustavo but decides to tie the knot anyways. On her wedding night, Gustavo shows up in their room, murders Eduardo, and proceeds to turn Ofelia into a vampire so that they can be together forever. In the present day 1960's, a group of young men and women take shelter in an abandoned lodge after their van breaks down. Soon, Ofelia appears and seduces one of the guys and meanwhile the girls go missing. It is up to the other guys to figure out what is happening and Ofelia must make a decision as to how much longer she can continue with her cursed life.