A wounded archaeologist crawls into the camp of three kindhearted cowboys. When the cowboys bring him to a nearby trading post, he's murdered after he lets slip a secret about a hidden cave. Investigating his death, Ken and his friends encounter a land dispute between a pair of neighboring ranches, an arrogant German baron and a mysterious shack that houses a great secret.
A mad scientist uses captured criminals as experiments for his study on "the criminal mind" aboard his private ship.
When Tex is brought in to fight in a range war between the cowmen and the nesters, he meets his old outlaw boss Lassiter. He learns Lassiter is behind the feud when Lassiter asks him to join up with his gang. Tex refuses and instead sets out to stop the feud but no one will believe him that Lassiter is responsible.
At the Brentwood Asylum for the mentally ill, psychiatrist partners Jane Everest and Alex MacGregor are broken up by the new superintendent, Dr. Charles Monet, who has a low regard for women physicians. Jane and Charles clash on patient treatment, and Jane learns that Charles has a sister, Claire, with a mysterious past.
An amateur sleuth solves three murders at his son's New England college.
After he inherits some money, Harold Bissonette ("pronounced bis-on-ay") decides to give up the grocery business, move to California and run an orange grove. Despite his family's objections and the news that the land he bought is worthless, Bissonette packs up and drives out to California with his nagging wife Amelia and children.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.