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Following his great success with "North by Northwest," director Alfred Hitchcock makes a daring choice for his next project: an adaptation of Robert Bloch's novel "Psycho." When the studio refuses to back the picture, Hitchcock decides to pay for it himself in exchange for a percentage of the profits. His wife, Alma Reville, has serious reservations about the film but supports him nonetheless. Still, the production strains the couple's marriage.
Rita heads to the mountains to get some peace and recover from mental distress. While there she meets Pierce, a doctor doing stem cell research whose experiments have gone horribly wrong. Now Rita is the only one who can solve the problem.