Texas Ranger Dusty Rivers ("Isn't that a contradiction in terms?", another character asks him) travels to Canada in the 1880s in search of Jacques Corbeau, who is wanted for murder. He wanders into the midst of the Riel Rebellion, in which Métis (people of French and Native heritage) and Natives want a separate nation. Dusty falls for nurse April Logan, who is also loved by Mountie Jim Brett. April's brother is involved with Courbeau's daughter Louvette, which leads to trouble during the battles between the rebels and the Mounties. Through it all Dusty is determined to bring Corbeau back to Texas (and April, too, if he can manage it.)
Homesteaders are moving into the valley settled many years ago by rancher Craig Dolan. He wants to keep them out by legal means but his nephew Bart brings in outlaws to drive them out. The Lone Ranger is on hand to help the homesteaders battle Bart's men as he overcomes traps, ambushes, burning buildings and other obstacles in his attempt to bring peace to the valley.
The Cattlemen's Association has called in the Mesquiteers to find cattle rustlers. They get Tex Riley to pose as Stony so Stony can arrive posing as a wanted outlaw. This gets Stony into the gang of rustlers and he alerts Tucson and Lullaby as to the next raid. But Hartley is on hand and unknown to anyone is the rustler's boss and he joins the posse with a plan that will do away with the Mesquiteers.
The local school is causing Hoppy problems. First Bar 20 cattle are stolen when Hoppy investigates a problem there. Then the new teacher arrives and disrupts the routine of the Bar 20 hands. Later with the Bar 20 hands at graduation, the rustlers are poised to strike again. But there is dissension among them and this will lead to the break that Hoppy needs.
Hoppy's friend Dennis owns a rich gold mine. Frazier who owns the adjoining mine and wants the Dennis mine, has Dennis killed. Hoppy steps in to take over running the Dennis mine and learns Frazier's men sneak into and work the Dennis mine at night. Hoppy captures one of Frazier's men only to be captured in return by Frazier and left to die in a burning building.
Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.
On a cattle drive Hoppy, camp cook Windy, companion Lucky, and young Artie Peters encounter an eccentric professor. The professor professes to be searching for the evolutionary missing link, but in reality he is a cattle rustler who uses his dynamite to scatter the cattle in order capture some of them. Hoppy and Bar 20 guys ultimately capture the professor.