Dexter and Royce, two stoner friends in Weedsville, scramble to cover up the apparent overdose of Royce's girlfriend, Mattie, by trying to bury her at a closed drive-in theater. Their plan goes sideways when they stumble into a Satanic cult mid-ritual, and Mattie unexpectedly comes back to life. Now pursued by the cult, they also face threats from local drug dealer Omar, demanding payment for a botched drug deal. In a desperate bid to settle their debt, Dexter and Royce steal a safe from a wealthy coma patient while evading the cult and Omar’s enforcers. The chaos culminates at a New Age center, where Mattie is nearly sacrificed, but the trio manages to escape after an explosive showdown that leaves both the cult and Omar neutralized. With their debt cleared and Mattie alive, Dexter and Royce flee the scene, barely escaping the insanity.
As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.