The Girls of Kappa Tau Omega are popular, pretty, and love to party! However, the party will soon be dead! There's an uninvited guest in their new sorority house whose motto is Kappa Kappa Kill! Who will survive this hellacious night of blood, babes, and butchering?
Manhattan drag queens Vida Boheme and Noxeema Jackson impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.