Marital fidelity can wear you down, and Ondra and Vitek are certainly suffering from a case of serious fatigue. Working side by side and living next door to each other, it doesn't take long before these two long-married middle-aged pals start comparing sex notes, and it's plain to see their latest scores have fallen far below what they would have hoped. Luckily, a surprise holiday on a tropical island rekindles their interest in their wives - only they don't exacly lust after their designated partners. With no one to divert their attention, their roaming eyes inevitably settle on the wrong spouse, and pretty soon they've established their own little Holy Quaternity.
Robert works for a travel agency and helps to arrange scenes from the everyday lives of "ordinary" Czech families as an attraction for Japanese tourists. He also works as a kind of matchmaker and occasionally helps to put together some of his friends. He helps to separate his friend Hanka from Peter, an announcer for an independent radio station who tries to capture "real" life by recording the moments from "reality" and playing them over the air. Vesna, came to Prague from Macedonia because it is according to her the best place for UFOs to land, but her real reason for coming is somewhat different... Hanka is followed by the crazy Ondrej, until then a respected brain surgeon, and married with two kids. Through him she meets Jacob, who uses copious amounts of weed in order to be constructive in this gloomy world. On the other hand, this destroys his short-term memory - and he forgets that he already has a girlfriend...
Maniac, a driver, sits on the track women, which then rape and kill. For loved ones, he is an ordinary person who has a wife and child. When exposed, he does not stop before killing his wife and takes his son hostage, under the guise of which he is trying to escape abroad.
Due to his profession, Fred, an easy-going and charming long-haul truck-driver, sees a lot of the world. Along his routes he enjoys the company of a lot of girlfriends who sweeten his spare time. One day, he suffers an accident in Prague which puts his co-driver Orje out of action. The beautiful Hungarian Jana persuades him to make her his new co-driver and does her utmost to take care of the stressful job. The more time the uneven couple spends on the road together, the more Jana feels attracted to Fred.
At the funeral of his schoolmate, the nearly-fifty-year old architect Jirí Mánek (Václav Voska) meets his former close acquaintance - physician Jarmila (Blanka Bohdanová). They both are still single. Jarmila has recently returned to Prague after years of work on the frontier. Jirí leaves for a business trip. As a conservationist, he is to grant permission for an adaptation of a Baroque château to office spaces. On the road, a pretty young hitchhiker named Eva (Ida Rapaicová) stops him. Eva is Slovak and her spontaneous behavior enchants Jirí. He thus does not mind making a short detour and takes Eva all the way to the luxurious cottage of her parents. A romance develops between the two people, so different in age and temperament.