With varying degrees of success, recently divorced friends Dave, Vic and Donny are trying to move on with their lives. Vic feels vilified by his ex-wife's parents, while Donny has a shaky bond with his teen daughter, Emma. Dave, meanwhile, has an enviable problem -- he has more dates than he can handle. As they confront their post-marital challenges, the men take solace in one another's plights.
A fire breaks out on the 12th floor of the First Interstate Tower building in Los Angeles. Meanwhile, Paul and Susan are working late on the 37th floor, along with cleaning staff, security, and building engineers, some of whom are installing sprinklers. The fire spreads rapidly and those in the building quickly become trapped.
A baby alligator is flushed down a toilet and survives by eating discarded lab animals that have been injected with growth hormones. The now gigantic animal escapes the city sewers and goes on a rampage, pursued by a cop and a big-game hunter.