After a near-death drowning accident, a young boy's family is horrified to discover he has become possessed by a legendary demon from the depths of the lake. As the family races against time to save the boy's soul, the evil monster inside the child tears the family apart as it seeks to destroy everyone in its path.
Thomas Kaiser inherits an ancestral mansion that has been in his family for generations — only to learn that he has also inherited an ancient curse stemming back to the Crusades. Forced into his new role as “protector” — the guardian appointed to keep the evil demons in the house at bay — Thomas teams with an ambitious local realtor and paranormal cleric to unravel the mystery of the house, while struggling to awaken the beautiful Briar Rose, held captive in a terrifying netherworld seen previously in his dreams.
When a brilliant but obsessive scientist goes to extremes to develop a universal cure for all disease, he finds himself infected with a bizarre parasite that begins to transform him into a bloodthirsty madman. Time running out, he must find a way to stop the monster that is growing within and prevent the rest of the world from being "cured."
Sarah, a mentally-disturbed teen, has a jarring premonition of her friends' impending deaths one night at a sleepover. As her house guests begin to turn murderously against each other, Sarah must determine whether her visions represent the preventable or the inevitable... or something entirely more sinister.