To be able to hide the hostages, a code is needed. Thanks to that a powerful and well known cartel trafficks undocumented people into the United States. The Department of Immigration has been behind this crew a while back but will be surprised when they find out who really is behind... ..."The Acordeon Code."
Innocent women are being kidnapped and used as guinea pigs for a brain transplant experiment. The diabolical Dr. Frankenstein continues his quest to perfect his brain transplant operation to bring back his deceased wife at any cost - even if it means playing with the lives of others. El Santo and Blue Demon are called in to help when their friend Alicia becomes Dr. Frankenstein's next target. It'll take both heroes to go up against the dastardly doctor and go mano a mano with his super strong zombie Golem.
Bumbling inventor/jack of all trades does sketch-comedy stuff for 65 minutes, then rescues Mexico City from a Mad Scientist triggering earthquakes.
After a group of violent lepers escapes from a sanitarium, - robbing several farms, residents of the town demand the the sheriff - take action. Meanwhile, a local criminal joins forces with the lepers - to commit even more robberies. As the disfigured madmen keep the - entire town indoors with its reign of terror, the sheriff has no - choice but to call on the only man who can help--legendary wrestling - superhero, Santo!