After a violent storm, a dense cloud of mist envelops a small Maine town, trapping David Drayton and his five-year-old son in a local grocery store with other local residents. They soon discover that the mist conceals deadly horrors that threaten their lives, and worse, their sanity.
Southern matriarch Madea has a lot on her plate. Her nieces, Vanessa and Lisa, have relationship troubles - Vanessa moves into Madea's house with her 2 young children and Lisa is engaged to a controlling man that her mother set her up with. In addition, Madea has just been court-ordered to become the guardian of Nikki, a rebellious runaway teenager. Madea must keep the peace and her family together while simultaneously planning her clan's reunion.
Ben Holmes, a professional book-jacket blurbologist, is trying to get to Savannah for his wedding. He just barely catches the last plane, but a seagull flies into the engine as the plane is taking off. All later flights are cancelled because of an approaching hurricane, so he is forced to hitch a ride in a Geo Metro with an attractive but eccentric woman named Sara.
In 1935, 99-year-old former slave Shadrach asks to be buried on the soil where he was born to slavery, and that land is owned by the large Dabney family, consisting of Vernon, Trixie and their seven children, and to bury a black man on that land is a violation of strict Virginia law.
Shelby Coles (Halle Berry) is engaged to marry talented white jazz musician Meade Howell, but the pair face opposition from both Meade's family, who object to an inter-racial marriage, and Shelby's parents, who want her to marry a professional. As Shelby is afflicted by pre-marital doubts, handsome Lute McNeil arrives on the scene, determined to make Shelby his at any cost.
Grace King Bichon, who is managing her father's riding-stable, discovers that her husband Eddie is deceiving her with another woman. After confronting him in the middle of the night on the streets of their small home town, she decides to stay at her sister Emma Rae's house for a while to make up her mind. Breaking out of her everyday life, she starts to question the authority of everyone.