Drug use in the city of Rome is at an all-time high. Children score from dealers in front of their schools, mules waltz straight through airport security, and Interpol's main man, Mike Hamilton, is at his wits' end. Fed up to the back teeth with the local police force's incompetence, his only hope is to rely on one of his own men, Fabio, an officer so deep undercover that no-one but Hamilton knows who he really is. Even as Fabio gains the trust of cartel leader Gianni, however, the dealers are edging ever closer to the truth, and when his cover is blown, the hunter becomes the hunted as Fabio finds himself alone in a desperate fight to survive.
Half-breed Keoma returns to his border hometown after service in the Civil War and finds it under the control of Caldwell, an ex-Confederate raider, and his vicious gang of thugs. To make matters worse, Keoma's three half-brothers have joined forces with Caldwell, and make it painfully clear that his return is an unwelcome one. Determined to break Caldwell and his brothers' grip on the town, Keoma partners with his father's former ranch hand to exact violent revenge.
Django comes to town to discover that his brother Steve, accused of robbing a bank, has been lynched. Django believes the real culprit is Sartana and challenges him to a duel. Just in time he discovers that the author of the crime is an important local figure and Django and Sartana join forces to punish him.
In 1866, prospector Tom Corbett returns to his hometown of Laramie, Texas, now under the brutal control of gangster Jason Scott and his violent son, Junior. With his brother Jeff, a struggling drunk cared for by their maid Mercedes, Tom seeks to overthrow the Scotts' tyrannical rule and restore peace to the town.