When wealthy Wall Street stockbroker Stephen Duane neglects his wife Julia for business, she consorts with philanderer Bert Brockwell. Finding them in an embrace forced by Brockwell, Stephen denounces Julia and leaves. After losing his fortune in the market, Stephen refuses Julia's offer to sell her jewels, and stays away for one year
Bessie Allen, a girl of the slums, dances in the streets of the Lower East Side of New York to the delight of the crowds. She becomes an orphan when her father, in a drunken stupor, kills her mother, and then himself. Bessie is knocked down by the car of Mrs. Latham, a society matron, who takes an interest in the girl and procures her a job as a dress model.
Having made public her disdain for wealthy men, musical comedy actress Elaine Elton is nonetheless ardently pursued by a handsome young millionaire who, for her sake, poses as his own chauffeur. A romance blossoms, but Elaine cannot accept the handsome millionaire's marriage proposal; she has already promised to marry a powerful producer who has threatened to blacklist her from Broadway if she refuses to become his bride.
Kathlyn Hare, daughter of Col. Hare, a collector of wild animals, is modeling a pet leopard in her alfresco studio, when her younger sister, Winnie, comes in with a collie dog, which excites the leopard into such ferocity that the sister has to seek safety in a cage.
A young woman who is engaged to a millionaire she doesn't love meets and falls in love with a rough sailor.
Moving Picture World described the film: "There is a small need to describe this subject as the poem of Lord Tennyson is so well known, so suffice it to say that this Biograph subject is an unusually faithful portrayal of that beautiful romance of Enoch Arden, Annie Lee and Philip Ray, taken in scenes of rare beauty".
Annie remains faithful to her husband, Enoch, even though he's been lost at sea for many years. Finally her grown children convince her to marry Philip, her former suitor. Enoch is rescued from the deserted isle where he has been stranded, and returns home. He discovers Annie's new life, and decides not to interrupt her happiness.
A young woman takes over her sick father's role as telegraph operator at a railway station, and has to deal with a team intent on train robbery.
An elderly carpenter is told by a doctor that his wife is seriously ill. Soon afterwards, an insensitive shop foreman lays him off from his job because of his age. Unable to find work, and with his wife's condition getting worse, he soon becomes desperate.
During the Civil War a young soldier loses his nerve in battle and runs away to his home to hide; his sister puts on his uniform, takes her brother's place in the battle, and is killed. Their mother, not wanting the shameful truth to become known, closes all the shutters (hence the film's title) and keeps her son's presence a secret for many years, though two boyhood chums stumble upon the truth...
After her mother's death, Ruth struggles to support herself as a seamstress. While Ruth delivers shirts to the factory owner, the owner's son steals some money and Ruth is accused of the crime. She flees the ghetto of New York's Lower East Side and hides in the country where she meets a young farmer.
Ramona, residing on her wealthy Spanish adoptive mother's rancho in California, falls in love with the Indian Alessandro. When Ramona is denied permission to marry Alessandro, the lovers elope, only to find a life of great hardship and unhappiness amidst the greed and injustice of the white landowners.