Shortly before graduating from medical school, Mariana returns home to fulfill her father's promise to celebrate the greatest wedding ever in the history of Castañer. Complications arise when the bride's and the groom's families come together for the wedding preparations and festivities.
Heaven is in chaos. God left for Earth to seek faith and hope in humanity. San Wichón stays in charge of the Celestial Senate and, in his campaign for the governorship, things get out of control. Disillusioned because Heaven is no longer a paradise, the girl angel María de las Estrellas (Mary of the Stars) descends to Earth to look for Heaven's top boss.