Augusto Castro can't stand the thought of his only sister Alice getting hitched to some monster man due to an old-school marriage pact from 15 years back. He decides to pull a fast one on the agreement and steps in to marry the notorious mob boss, Pietro, in her place. Little did he know, it was all a love trap set by Pietro.
A group of friends, in dire need of cash, find themselves at a secluded medical trial retreat in what seems like an easy way to earn money but quickly turns into their worst nightmare. Under the guise of a harmless experiment run by the enigmatic Dr. Feldman, they are about to face a horror they never imagined. Unbeknownst to them, Dr. Feldman has unleashed a new terror: a swarm of genetically engineered killer flies, with an insatiable thirst for human blood.