An American girl on vacation in Italy finds an unanswered "letter to Juliet" -- one of thousands of missives left at the fictional lover's Verona courtyard, which are typically answered by the "secretaries of Juliet" -- and she goes on a quest to find the lovers referenced in the letter.
Stefano is now forty years old but has not yet found his purpose in life, remaining an eternal dreamer waiting for that decisive enlightenment. With his parents who have great plans for him, Stefano realizes that he lost most of his years without a real goal and thinks back to all those missed opportunities that could have led him to another path, between old loves and unexploited opportunities .
Valentina, a beautiful fashion model, takes an experimental drug as part of a scientific experiment. While influenced by the drug, Valentina has a vision of a young woman being brutally murdered with a viciously spiked glove. It turns out that a woman was killed in exactly the same way not long ago and soon Valentina finds herself stalked by the same killer.