A few decades after the destruction of the Inca Empire, a Spanish expedition led by the infamous Aguirre leaves the mountains of Peru and goes down the Amazon River in search of the lost city of El Dorado. When great difficulties arise, Aguirre’s men start to wonder whether their quest will lead them to prosperity or certain death.
In 1920, an unknown 24-year-old woman was fished out of Berlin's Landwehr kanal after a suicide attempt. Since she has no papers and no answers to any questions, they soon assign them to the insane asylum Dallendorf. A co-patient believes she recognizes the Czar's daughter Anastasia Romanowa - who apparently was the only one who survived the murder of the tsar's family in 1918.