From the heights of notoriety to the depths of depravity, John Forbes Nash Jr. experiences it all. As a brilliant but socially awkward mathematician, he made a groundbreaking discovery early in his career and stands on the brink of international acclaim. But as the handsome and arrogant Nash accepts secret work in cryptography, he becomes entangled in a mysterious conspiracy. His life takes a nightmarish turn and he soon finds himself on a painful and harrowing journey of self-discovery.
Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.
Henry Hackett is the workaholic editor of a New York City tabloid. He loves his job, but the long hours and low pay are leading to discontent. Also, publisher Bernie White faces financial straits, and has hatchet-man Alicia Clark—Henry's nemesis—impose unpopular cutbacks.
After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.