After losing his wife seven years earlier, the eccentric Dr. John Dolittle, famed doctor and veterinarian of Queen Victoria’s England, hermits himself away behind the high walls of Dolittle Manor with only his menagerie of exotic animals for company. But when the young queen falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and discovers wondrous creatures.
Zarina, a smart and ambitious dust-keeper fairy who’s captivated by Blue Pixie Dust and its endless possibilities, flees Pixie Hollow and joins forces with the scheming pirates of Skull Rock, who make her captain of their ship. Tinker Bell and her friends must embark on an epic adventure to find Zarina, and together they go sword-to-sword with the band of pirates led by a cabin boy named James, who’ll soon be known as Captain Hook himself.
After the disastrous food storm in the first film, Flint and his friends are forced to leave the town. Flint accepts the invitation from his idol Chester V to join The Live Corp Company, which has been tasked to clean the island, and where the best inventors in the world create technologies for the betterment of mankind. When Flint discovers that his machine still operates and now creates mutant food beasts like living pickles, hungry tacodiles, shrimpanzees and apple pie-thons, he and his friends must return to save the world.