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Duetto takes place in 1965 and tells the story of 18-year-old Cora, a Brazilian from an Italian family who, after losing her dad in a tragic car accident, goes with her grandmother Lucia to Puglia, Italy, where her ancestral homestead still stands. Lucia, aiming to sell an old family land lot, reencounters her sister Sofia and her husband Gino, whom she hasn't spoken to in 40 years.
Dona Hermínia is back, but now rich and famous since she is the host of her own successful TV show. However, the overprotective character will have to deal with her children's departures, as Marcelina and Juliano decide to move out. In counterpart, she will welcome, as a visitor, her sister Lúcia Helena, who's been living in New York.