Farmer Jabez Stone, about to lose his land, agrees to sell his soul to the devil, known as Mr. Scratch, who gives Jabez seven years to enjoy the fruits of his sale before he collects. Over that time, Jabez pays off his debts and helps many neighboring farmers, then becomes an advocate for the upstanding Sen. Daniel Webster. When Jabez's contract with Mr. Scratch concludes, he desperately turns to Webster to represent him in a trial for his soul.
In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.
Carrie Snyder is a prostitute, who is forced out of the fictional southern town of Crebillon, after forming a friendship with a young boy named Paul, whose dying mother is unable to protest against her son visiting such a woman. After Carrie has left town Paul runs away from his abusive father, and meets a girl named Lady who has run away from a burning trainwreck, not wanting to go back to the people she was with. Carrie comes back for Paul and ends up taking Paul and Lady to New York with her.
Longfellow Deeds lives in a small town, leading a small town kind of life. When a relative dies and leaves Deeds a fortune, Longfellow moves to the big city where he becomes an instant target for everyone. Deeds outwits them all until Babe Bennett comes along. When small-town boy meets big-city girl anything can, and does, happen.
Poor abused Nora runs into privileged bored Beatrice while wandering onto the rich girl's family estate. Both girls notice the uncanny resemblance between each other, so they decide to switch places. However, trouble soon arises for both girls in their new roles.