Josephine Spiggins is thinking of marrying John Spear, the stuffed-shirt son of a department store owner. When John's free-spirit brother Tony returns from touring the South Seas in his boat, the "Vagabond Lady," Jo is attracted to him instead.
Sassy and ambitious waitress Mary Evans amuses and befriends amiable seldom-sober Hollywood film director Max Carey when he stumbles into her restaurant. Max invites Mary to his film premiere and, after a night of drinking and carousing, Mary is granted a screen test. A studio contract follows. Just as Mary finds her dreams coming true, Carey’s life and career begins its descent.
In 1877, thieves Ace Beaudry, Bronco Dawson and Bull Stanley head West together after having each been betrayed by a woman. They come across a wagon train bound for the town of Custer, where hundreds of people are gathering for a land rush in the Dakotas, which President Ulysses S. Grant has opened to settlers thanks to a treaty with the Sioux Indians. After the three rogues ride off, they spy a lone wagon with a tempting string of thoroughbreds. Before they can steal the horses, however, the wagon is attacked by a gang led by Layne Hunter, a shifty saloon owner from Custer. The trio chase off the gang, and as they are about to abscond with the horses, they find pretty Lee Carleton, whose father was killed in the attack.
Mimi, an unsophisticated American girl attending an exclusive Swiss boarding school, unexpectedly inherits a large fortune. Returning to the United States she quickly begins to live a wild and reckless life. Good-natured Joe attempts to set her straight, but she keeps right on living riotously. It takes Mimi a serious accident while joyriding to comes to her senses and realize she is ready for a more settled existence.
Doctor James Leland is a successful doctor engaged to nurse Marion Nord. Working late one night he discovers his assistant stealing the supply of cocaine. The doctor is knocked unconscious and his body is dump assuming, incorrectly, that the good doctor is dead.