Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
It's just after the Civil War and Ben Shelby arrives looking for Johnny Tallon whom he plans to kill. Shelby was the only survivor of a battle due to the cowardice of Tallon. Thinking Tallon dead, another man who lost a brother at the same battle arrives to kill Tallon's blind brother. Tallon arrives to find Shelby and his brother fleeing. Then they are attacked by Indians and Shelby and Tallon must now fight together postponing the inevitable showdown.
Dardo, a Robin Hood-like figure, and his loyal followers use a Roman ruin in Medieval Lombardy as their headquarters as they conduct an insurgency against their Hessian conquerors.
Two young horse traders guide a Mormon wagon train to the San Juan Valley and encounter rugged terrain, the cutthroat Clegg gang, hospitable Navajo, and moral challenges on the journey.
Newspaper magnate Charles Foster Kane is taken from his mother as a boy and made the ward of a rich industrialist. As a result, every well-meaning, tyrannical or self-destructive move he makes for the rest of his life appears in some way to be a reaction to that deeply wounding event.
Wild Bill Hickok, Calamity Jane and Buffalo Bill go up against Indians and a gunrunner.